Home/Synergies

Card Synergy Browser

Every card in Slay the Spire 2 fits into one or more synergy mechanics. Pick a mechanic below to see which cards produce the effect, which cards benefit from it, and the strongest combos for each character.

19Synergy Mechanics

547Cards Analysed

5Characters

Filter by character:

Debuffs

Vulnerable

209 cards

Vulnerable makes enemies take 50% more damage from attacks

Ironclad 65Silent 55Defect 53Necrobinder 47Regent 56

Weak

16 cards

Weak causes enemies to deal 25% less damage

Ironclad 2Silent 6Defect 3Necrobinder 3Regent 6

Poison

12 cards

Poison deals damage at the start of enemy turns

Silent 12

Buffs

Strength

21 cards

Strength adds extra damage to every attack

Ironclad 9Silent 3Defect 3Necrobinder 1Regent 6

Dexterity

96 cards

Dexterity adds extra Block to every block-granting card

Ironclad 31Silent 31Defect 28Necrobinder 27Regent 27

Block Build

99 cards

Cards that generate or benefit from Block

Ironclad 34Silent 31Defect 27Necrobinder 27Regent 27

Card Manipulation

Card Draw

57 cards

Draw extra cards for more options each turn

Ironclad 16Silent 16Defect 19Necrobinder 13Regent 16

Exhaust

110 cards

Exhaust removes cards from play, triggering certain effects

Ironclad 42Silent 29Defect 33Necrobinder 32Regent 25

Discard

32 cards

Discard synergies benefit from throwing away cards

Ironclad 4Silent 11Defect 10Necrobinder 7Regent 2

Retain

16 cards

Retain keeps cards in your hand between turns

Ironclad 4Silent 7Defect 4Necrobinder 10Regent 5

Scry

0 cards

Scry lets you look at and discard cards from the top of your draw pile

Resources

Energy

0 cards

Extra energy lets you play more cards per turn

Orbs (Defect)

Orbs

37 cards

Orbs provide passive and active effects for the Defect

Defect 37

Focus

43 cards

Focus increases the passive effect of all Orbs

Defect 43

Stances (Regent)

Stance

0 cards

Stances provide powerful but risky buffs

Summons (Necrobinder)

Summon

16 cards

Summon and empower minions to fight alongside you

Ironclad 1Necrobinder 12Regent 3

Other

Self-Damage

19 cards

Cards that cost HP to play, pairing with lifesteal or HP-based effects

Ironclad 10Silent 1Defect 1Necrobinder 5

Ethereal

46 cards

Ethereal cards are exhausted if not played by end of turn

Ironclad 19Silent 2Defect 4Necrobinder 19Regent 4

Status Cards

10 cards

Create or benefit from Status cards in your deck

Defect 10

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